NCT05639244

Time Restricted Eating and Innate Immunity

Effect of Short Term Time Restricted Eating on Innate Immunity in Patients With Coronary Artery Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this cross over study is to investigate the effect of short term time restricted eating (TRE) on the innate immune system in patients with a history of myocardial infarction.

Detailed description

In the recent years, research has shown the prominent role of low grade systemic inflammation in cardiovascular disease (CVD) and the crucial role myeloid cells, mainly monocytes and macrophages, play in atherogenesis. Time restricted eating (TRE), i.e. eating the normal amount of calories within a limited time period per day, has a beneficial effect on multiple factors involved in the development of CVD, such as blood pressure, heart rate, lipid and blood glucose levels, and insulin sensitivity. TRE also reduces markers of systemic inflammation and reduces the number of circulating monocytes. It is now hypothesized that TRE reduces the pro-inflammatory monocyte phenotype of patients with a history of myocardial infarction. Therefore, the investigators will perform a exploratory prospective randomised open label blinded endpoint cross-over study to investigate the effect of short term TRE on the innate immune system in patients with a history of myocardial infarction.

Conditions

• Time Restricted Feeding
• Myocardial Infarction
• Atherosclerotic Cardiovascular Disease

Interventions

Type	Name	Description
BEHAVIORAL	Time restricted eating (TRE)	Participants have to consume their regular food intake during a 6 hour period per day for 2 weeks.
BEHAVIORAL	Regular diet	Participants have to consume their regular diet within an unrestricted time period for 2 weeks

Timeline

• Start date: 2022-11-17
• Primary completion: 2024-01-25
• Completion: 2024-01-25
• First posted: 2022-12-06
• Last updated: 2024-03-27

Locations

1 site across 1 country: Netherlands