NCT05634655

Dissecting the Mechanism of DNA Methylation on the Invasiveness of Pituitary Tumors.

Dissecting the Mechanism of DNA Methylation on the Invasiveness of Pituitary

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

DNA methylation is one of the important ways of protein post-translational modification.Pituitary adenoma (PA) is a benign neuroendocrine tumor that originates from adenohypophysial 45 cells, and accounts for 10%-20% of all primary intracranial tumors. However some PAs can present with high invasiveness and irregular growth, which tend to compresses the optic chiasm and third ventricle, encase the internal carotid artery, and affect hormone secretion from the pituitary gland and hypothalamus. In this study we focus on the mechanism of DNA methylation on the invasiveness of pituitary tumors.

Conditions

• Pituitary Tumors

Interventions

Type	Name	Description
OTHER	no interventions between two groups	no interventions between two groups

Timeline

• Start date: 2022-01-01
• Primary completion: 2022-12-31
• Completion: 2025-01-01
• First posted: 2022-12-02
• Last updated: 2022-12-02

Locations

1 site across 1 country: China