NCT05630326

Association Between COVID-19 and UTIs Caused by ESBL Organism in Infants

Clinical, Laboratory, and Radiological Characteristics of Urinary Tract Infections in Infants With COVID-19

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 5,600 (actual)
• Sponsor: Hamad Medical Corporation · Industry
• Sex: All
• Age: 1 Year
• Healthy volunteers: Not accepted

Summary

Urinary tract infections (UTIs) in infants and young children are one of the most common bacterial infections, usually febrile illness without source, frequently due to Enterobacteriaceae, mainly Escherichia coli. Multidrug-resistant organisms including extended-spectrum beta-lactamase (ESBL) producing bacteria are becoming more prevalent. Due to the risk factors of ESBL-producing organisms in community-acquired (CA)-UTIs in infants in QATAR and Arab countries are still not studied because of the limited therapeutic options. hence, the importance of this study is to get knowledge about how to decrease the rapidly increasing in ESBL- producing bacteria, in infants, and to use antibiotics in a suitable guideline.so, The aim of this retrospective case-control study is to determine the clinical manifestations, and investigations of urinary tract infections among infants and the association with COVID-19 infection, in pediatric emergency centers at Hamad General Hospital - Qatar. From 1st January 2015 till 1st January 2022.

Detailed description

In this retrospective, case-control study investigators will include all infants (0-1 year) with UTIs who were treated at Hamad General Hospital, pediatric division- PEC Doha, Qatar, using the electronic medical records from 1st January 2015 till January 1st, 2022, diagnosed by a positive urine culture. Investigators will look for the clinical manifestations, radiological and laboratory findings, renal scarring, ESBL-organisms, prevalence, median age, gender, and ethnic background. Participants are divided into two groups: early infancy and late infancy, ESBL UTIs and non-ESBL UTIs, and upper UTIs and lower UTIs. Finally, UTIs ESBL with COVID-19 and without COVID\_19.

Conditions

• Renal Insufficiency

Interventions

Type	Name	Description
OTHER	comparing, prevalence	Comparing infants with UTIs caused by ESBL organism, or non ESBL organism.
OTHER	assessment	comparing infants with UTIs caused by ESBL organism, or non ESBL organism.
OTHER	association	comparing ESBLUTI with COVID-19 and ESBL UTI without COVID-19
OTHER	evaluation	comparing ESBLUTI with COVID-19 and ESBL UTI without COVID-19

Timeline

• Start date: 2023-03-01
• Primary completion: 2023-07-01
• Completion: 2023-07-20
• First posted: 2022-11-29
• Last updated: 2023-07-27

Locations

1 site across 1 country: Qatar