NCT05628454

Comparison of Three Different Puncture Techniques in EBUS-TBNA

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Beijing Friendship Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study was to compare the accuracy and sensitivity of slow-pull capillary technique, traditional suction aspiration and non negative pressure puncture in the diagnosis of mediastinal and/or hilar lymph node enlargement by ultrasound bronchoscopic lymph node biopsy.

Detailed description

EBUS-TBNA has been widely used in the diagnosis of diseases involving lung hilar and mediastinal lymph node enlargement.But different puncture methods are still controversial. Research shows that there was no significant difference in sample adequacy, diagnostic specificity and accuracy between the no negative pressure aspiration and traditional negative pressure aspiration technique.Slow-pull capillary technique is a relatively new operating method of endoscopic ultrasound guided fine needle biopsy in recent years. At present, this technology is widely used in pancreatic space occupying lesions. Compared with the traditional negative pressure aspiration method, our previous retrospective study found that the slow-pull capillary technique can improve the diagnostic accuracy of patients. Therefore, the purpose of this study is to prospectively and randomly compare the advantages and disadvantages of three puncture methods in EBUS-TBNA.

Conditions

• Lung Cancer
• Sarcoidosis
• Tuberculosis

Interventions

Type	Name	Description
PROCEDURE	Endobronchial ultrasound-guided transbronchial needle Slow-pull capillary sampling	The slow-pull capillary technique was performed as follows: after identification and measurement of the target lymph node, a needle was used to puncture the lymph node with the stylet in place.At the same time, the stylet was slowly and continuously pulled to create weak negative pressure.
PROCEDURE	Endobronchial ultrasound-guided transbronchial needle aspiration	The operation steps are the same as above, but the negative pressure device of 10ml syringe is connected behind the puncture needle.
PROCEDURE	Endobronchial ultrasound-guided transbronchial needle capillary sampling	The operation steps are the same as above, but there is no negative pressure device behind the puncture needle

Timeline

• Start date: 2022-11-08
• Primary completion: 2024-06-01
• Completion: 2024-11-01
• First posted: 2022-11-28
• Last updated: 2025-04-30

Locations

1 site across 1 country: China