NCT05626907

Does What You Eat Affect Your Brain

Assessing the Effect of Diet on Hypothalamic Gliosis in Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: University of Washington · Academic / Other
• Sex: All
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to use magnetic resonance imaging (MRI) to evaluate the human hypothalamus for signs of inflammation in response to specific diets. This research may lead to a better understanding of how poor nutritional quality may lead to obesity through effects on regions of the brain known to regulate body weight.

Conditions

• Gliosis
• Obesity
• Eating

Interventions

Type	Name	Description
OTHER	Diet modification #1	Participants will be provided all meals for a 14-day period. For 7 of the days, meals will be 130% of estimated daily caloric needs and for the other 7 days, meals will be low in calories, consistent with recommendations for weight loss.
OTHER	Diet modification #2	Participants will be provided all meals for a 14-day period. For 7 of the days, meals will be 150% of estimated daily caloric needs and for the other 7 days, meals will be meals will be low in calories, consistent with recommendations for weight loss.
OTHER	Diet modification #3	Participants will be provided all meals for a 14-day period to be approximately 100% of estimated daily caloric needs.

Timeline

• Start date: 2023-01-13
• Primary completion: 2025-01-28
• Completion: 2025-06-30
• First posted: 2022-11-25
• Last updated: 2025-08-29

Locations

1 site across 1 country: United States