NCT05625945

Physical Activity Levels and Statin Therapy

Physical Activity Levels and Statin Therapy: Differences Between Symptomatic and Asymptomatic Statin Users

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 196 (actual)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Rationale: Combining statin treatment and physical activity is very effective for the prevention of cardiovascular diseases. Statins are well-tolerated by most patients, but may cause statin-associated muscle symptoms (SAMS). Objective: To identify predictors for SAMS in statin users and to objectively assess physical activity levels and sedentary time between symptomatic and asymptomatic statin users.

Detailed description

Combining statin treatment and physical activity is very effective for the prevention of cardiovascular diseases. Statins are well-tolerated by most patients, but may cause statin-associated muscle symptoms (SAMS). Physical activity may exacerbate SAMS, producing decreased physical activity levels or statin nonadherence. However, it is unknown if daily activity patterns differ between symptomatic and asymptomatic statin users. In this cross-sectional observational study the investigators will assess if physical activity levels and sedentary time differ between symptomatic and asymptomatic statins users. Secondly, questionnaires will be used to assess predictors of SAMS.

Conditions

• Cardiovascular Diseases
• HMG COA Reductase Inhibitor Adverse Reaction
• Muscle Pain

Interventions

Type	Name	Description
BEHAVIORAL	Physical activity monitoring	Physical activity patterns will be measured using the activPAL3 micro monitor

Timeline

• Start date: 2021-01-01
• Primary completion: 2023-11-16
• Completion: 2023-11-16
• First posted: 2022-11-23
• Last updated: 2023-11-18

Locations

1 site across 1 country: Netherlands