NCT05625503

Dilution of Verapamil During Intraarterial Administration

Does Dilution of Verapamil With Normal Saline or Blood Reduce Discomfort Felt During Intraarterial Administration?

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 55 (actual)
• Sponsor: University of Illinois at Chicago · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will be a randomized, single-blind, prospective trial designed to evaluate the efficacy and safety of intra-arterial (IA) Verapamil diluted with normal saline compared to undiluted IA Nicardipine during transradial access (TRA) for percutaneous coronary angiography. Patients who are 18 years or older and undergoing non-emergent percutaneous coronary angiography via TRA will be included. Patients who are non-English speaking, pregnant, or intubated will be excluded. Patients will be randomized to one of the two following groups: 1. Group 1 will receive IA Verapamil 5 mg (2mL) diluted with 8 mL of normal saline 2. Group 2 will receive IA Nicardipine 400 mcg (undiluted, 8 mL) The investigators will document the patient's level of discomfort on the Visual Analogue Scale 30 seconds before and after administration of IA Verapamil/Nicardipine. The investigators will also document the presence of radial artery spasms.

Conditions

• Vasospasm;Peripheral
• Burning
• Pain

Interventions

Type	Name	Description
DRUG	Verapamil	All patients routinely receive intra-arterial calcium channel blockers during transradial access for coronary angiography.
DRUG	Nicardipine	Calcium channel blocker

Timeline

• Start date: 2022-12-13
• Primary completion: 2023-12-01
• Completion: 2023-12-01
• First posted: 2022-11-23
• Last updated: 2024-11-27

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study