NCT05624333

Vegan Diets: the Short-term Effects on Daily Muscle Protein Synthesis Rates as Compared to Omnivorous Diets in Older Adults Assessed by D2O.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 38 (actual)
• Sponsor: Wageningen University · Academic / Other
• Sex: All
• Age: 65 Years – 79 Years
• Healthy volunteers: Accepted

Summary

Consumers are increasingly encouraged to consume more plant-based foods and lower their consumption of foods from animal origin. However, the consequences of such a transition on muscle mass still remains to be explored. This is of particular importance in the older population, where sarcopenia is highly prevalent. The aim of this randomized controlled cross-over study is to investigate the short-term effect of a 10-day controlled vegan diet on daily muscle fractional synthesis rates in comparison to a 10-day controlled omnivorous diet in 35 community-dwelling older adults. Participants will follow a fully controlled vegan diet, directly followed by a fully controlled omnivorous diet for 10 days, or vice versa. Researchers will compare the effect of the vegan diet to the effect of the omnivorous diet.

Conditions

• Sarcopenia

Interventions

Type	Name	Description
OTHER	Vegan diet (intervention)	The intervention diet will be a fully controlled vegan diet that will be consumed for a duration of 10 days. No animal-based food products will be included in the diet.
OTHER	Omnivorous diet (control)	The control diet will be an a priori composed controlled omnivorous diet with a duration of 10 days. The omnivorous diet and the vegan diet will be isocaloric and isonitrogenous.

Timeline

• Start date: 2023-01-09
• Primary completion: 2023-02-13
• Completion: 2023-02-13
• First posted: 2022-11-22
• Last updated: 2023-03-24

Locations

1 site across 1 country: Netherlands