Trials / Recruiting

RecruitingNCT05621369

Psorcast Mobile Study

Psorcast Study: A Smartphone-based Study of Psoriasis and Psoriatic Arthritis

Status: Recruiting
Phase: —
Study type: Observational
Enrollment: 1,000 (estimated)

Sponsor: Sage Bionetworks · Academic / Other
Sex: All
Age: 18 Years
Healthy volunteers: Accepted

Summary

The purpose of this study is to understand variation in the symptoms of psoriasis and psoriatic arthritis using simple, scalable smartphone-based measurements. This study uses an iPhone app to record these symptoms through questionnaires and sensors.

Detailed description

Psoriatic disease exhibits a spectrum of symptoms and can transition from psoriasis (PsO), largely affecting the skin, to psoriatic arthritis (PsA) involving widespread musculoskeletal inflammation. Early detection of the PsO-to-PsA transition and rapid administration of effective treatment is essential, as a delay in diagnosing PsA by as little as 6 months can lead to irreversible joint damage. This "ticking clock" paradigm drives the need for frequent monitoring and effective therapeutic intervention as early as possible to attenuate or possibly prevent disease progression. Using a suite of smartphone-based measurements in an app called Psorcast (psoriasis forecasts), we aim to aggregate weekly, symptom measurements from participants in a remote, longitudinal observational study to map the trajectories of treatment response and disease progression. In this study, we will explore measurements of psoriatic disease activity at least an order of magnitude more frequently (weekly vs. quarterly) than standard clinical practice or clinical trial designs. This study is not meant to provide a medical diagnosis, treatment, or medical advice. It is meant to provide a scalable, inexpensive, non-invasive and frequent measure and tracking of psoriasis and psoriatic arthritis for research purposes.

Conditions

Interventions

Type	Name	Description
BEHAVIORAL	Participant self-assessment surveys	At enrollment, participants are asked to complete a baseline health history, family history, and a participant-reported symptom inventory.
BEHAVIORAL	Psoriasis Draw	Participants are asked to draw the location and size of psoriasis they currently experience. Participants are provided a body template onto which they can draw on their screen. Investigators estimate the percentage of body area affected.
BEHAVIORAL	Psoriasis Area Photo	Participants are asked to take a picture of a representative psoriasis plaque and indicate the location of the plaque. They are asked to take a picture of the same area over time. The investigators are developing computer vision algorithms to assess the plaque.
BEHAVIORAL	Finger and Toe Photos	Participants are asked to take pictures of the back of each hand and the top of each foot. These photos can be used to assess finger and toe swelling as well as psoriatic nail involvement. The investigators are developing computer vision algorithms to assess psoriatic nail involvement and digit swelling.
BEHAVIORAL	Digital Jar Open	Participants are asked to internally and externally rotate the phone as it rests on a flat surface. Participants perform each direction (internal and external) and each arm (left and right) in turn. Gyroscope sensors measure the degree of rotation.
BEHAVIORAL	30 Second Walk	Participants are asked to walk in a straight line for 30 seconds. Gait is measured by gyroscope and accelerometer sensors. The investigators examine step-dependent and sequence-dependent features from these sensors. The investigators apply feature selection and classifier algorithms to analyze these data.
OTHER	Psorcast mobile application	Participants complete all described behavioral interventions via a dedicated iPhone app, Psorcast.

Timeline

Start date: 2022-01-01
Primary completion: 2027-01-31
Completion: 2027-01-31
First posted: 2022-11-18
Last updated: 2025-06-11

Locations

1 site across 1 country: United States

Source: ClinicalTrials.gov record NCT05621369. Inclusion in this directory is not an endorsement.