NCT05618119

[18F]MC225 PET to Evaluate Gender Differences in BBB P-gp Function

The Impact of Gender Differences in P-glycoprotein Function Measured With [18F]MC225 and PET

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: University Medical Center Groningen · Academic / Other
• Sex: All
• Age: 50 Years – 80 Years
• Healthy volunteers: Accepted

Summary

P-gp is one of the main efflux transporters at the blood-brain barrier and is responsible for the transport of a variety of neurotoxic substances, including pharmaceuticals. Multiple studies report gender differences in therapeutic outcomes, toxicity and side effects for many drug agents. P-gp plays an important role in the bio-availability, drug distribution, metabolism and elimination of pharmaceuticals labelled as P-gp substrates (e.g. the majority of antidepressants and antipsychotics). A difference in P-gp function was already reported in hepatic P-gp expression. The aim of the current study is to evaluate the influence of gender on cerebral P-gp function. Outcomes of this study can be of great importance in gender-based prescription of P-gp substrate pharmaceuticals.

Conditions

• Gender

Interventions

Type	Name	Description
DRUG	[18F]MC225	\[18F\]MC225 PET scan

Timeline

• Start date: 2023-01-01
• Primary completion: 2024-01-01
• Completion: 2025-01-01
• First posted: 2022-11-16
• Last updated: 2022-11-16