NCT05616377

Combination of Local Therapy and Target Therapy for Brain Metastases With EGFR Mutation

Survival Benefit of Combination of Local Therapy and Target Therapy for Brain Metastases With EGFR Mutation: A Multicenter Retrospective Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 2,000 (estimated)
• Sponsor: Sun Yat-sen University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to learn about the survival benefit of local therapy combination with target therapy in lung cancer brain metastases with EGFR mutation. The main questions it aims to answer are: * Is local therapy performed before or after target therapy would provide survival benefit ? * What kind of local therapy combining with target therapy would provide survival benefit, neurosurgical resection or radiotherapy?

Conditions

• Brain Metastases

Interventions

Type	Name	Description
OTHER	Surgery or Radiotherapy	Participants who underwent target therapy and surgery or radiotherapy were divided into target therapy + local therapy group. Participants who underwent target therapy alone were divided into target therapy alone group
OTHER	before or after target therapy	Participants who underwent surgery or radiotherapy before target therapy were divided into local therapy before target therapy group. Participants who underwent surgery or radiotherapy after target therapy were divided into local therapy after target therapy group.

Timeline

• Start date: 2022-11-20
• Primary completion: 2023-08-20
• Completion: 2024-11-20
• First posted: 2022-11-15
• Last updated: 2022-11-15