NCT05613452

Carbon Ion Therapy for Peripheral Non-small Cell Lung Cancer

Prospective Phase II Clinical Study of Carbon Ion Beam Stereotactic Radiotherapy for Peripheral Type Early-stage Non-small Cell Lung Cancer

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 43 (estimated)
• Sponsor: Shanghai Proton and Heavy Ion Center · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

To investigate the efficacy of carbon ion therapy for stage Ia-IIa primary peripheral non-small cell lung cancer (NSCLC). The primary endpoint was progression-free survival (PFS), and the secondary endpoint was local control rate, overall survival (OS) and toxicities.

Conditions

• Non-small Cell Lung Cancer

Interventions

Type	Name	Description
RADIATION	Carbon ion beam radiotherapy	Patients receive carbon ion radiotherapy of 12GyE per fraction, totally 4 fractions. Patients with tumors ≥4cm should receive at least 4 cycles of platinum-based doublet chemotherapy.

Timeline

• Start date: 2024-09-29
• Primary completion: 2025-12-31
• Completion: 2026-12-31
• First posted: 2022-11-14
• Last updated: 2025-06-13

Locations

1 site across 1 country: China