NCT05612789

Improve Outcomes for Older Allogeneic Transplant Recipients

Intervening on Frailty to Improve Outcomes for Older Allogeneic Transplant Recipients

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 72 (estimated)
• Sponsor: Abramson Cancer Center at Penn Medicine · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

This is an interventional pilot study to determine whether implementation of a supervised exercise program can improve outcomes in subjects undergoing allogeneic HCT. The primary objective is to determine feasibility. Up to 60-72 evaluable subjects will be enrolled. Evaluable subjects are defined as those participating in the exercise intervention.

Conditions

• Allogeneic Transplantation

Interventions

Type	Name	Description
BEHAVIORAL	Exercise Program (Cohort A Prehab)	Pre-frail and frail potential HCT recipients 60 years and older will participate in a supervised exercise program from the time of enrollment up until HCT admission. Exercise compliance will be measured in part through physical activity trackers.from time of discharge from HCT until day +100 post-HCT. All HCT recipients 60 years and older will participate in a supervised exercise program from the time of discharge from HCT admission until day +100 post-HCT. Exercise compliance will be measured in part through physical activity trackers.
BEHAVIORAL	Exercise Program (Cohort B Rehab)	All HCT recipients 60 years and older will participate in a supervised exercise program from the time of discharge from HCT admission until day +100 post-HCT. Exercise compliance will be measured in part through physical activity trackers.

Timeline

• Start date: 2023-02-15
• Primary completion: 2030-06-01
• Completion: 2031-06-01
• First posted: 2022-11-10
• Last updated: 2025-12-10

Locations

1 site across 1 country: United States