NCT05612659

Developing an EEG Probe for Studying and Modulating Cognitive Control

Developing an EEG Probe for Studying Effects of Non-invasive Cortical and Spinal Cord Electrical Stimulation on Cognitive Control in Post Stroke Depression

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: University of Cincinnati · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This study aims to investigate effects of transcranial current stimulation (tES) and transcutaneous direct current stimulation (tsDCS) associated changes on fronto-parietal EEG and cognitive performance in patients with post stroke depression (PSD)

Detailed description

The investigators will perform a double blind, randomized, sham controlled, crossover study design to assess effects of tES, tsDCS and sham stimulation on the performance during a cognitive control task. The working Hypothesis is tsDCS and/or tES will enhance frontal theta oscillations as recorded on EEGs and improve task performance compared to sham stimulation. Results from this project can potentially lead to the development of a new research tool for assessing neuromodulation strategies to treat mental disorders and their comorbidities. It will also uncover the neural correlates of cognitive deficits in PSD and provide feasible biomarkers associated with treatment response in support of a larger clinical.

Conditions

• Post-stroke Depression

Interventions

Type	Name	Description
PROCEDURE	Transcranial Electrical stimulation	Noninvasive electrical stimulation of lateral frontal cortex.
PROCEDURE	Transcutaneous direct current stimulation	Noninvasive electrical stimulation of the T10 spinal column.

Timeline

• Start date: 2022-09-28
• Primary completion: 2024-03-31
• Completion: 2024-05-30
• First posted: 2022-11-10
• Last updated: 2024-06-27

Locations

1 site across 1 country: United States