NCT05609331

Feasibility, Safety, and Efficacy of Stereotactic MRI-Guided Adaptive Radiation Therapy (SMART) for Central Lung Tumors

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 3 (actual)
• Sponsor: M.D. Anderson Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To learn if using MRI (magnetic resonance imaging) to guide radiation therapy can help to control central lung cancer. The results of the MRI-guided radiation therapy will be compared to conventional radiation therapy (guided by CT scans) during this study.

Detailed description

Primary Objective: Stage I: Assess the feasibility of SMART for central lung tumors with simulated online adaptive planning. Stage II: Evaluate the feasibility and safety of SMART in central lung tumors treated with 50Gy in 4-5 fractions. Secondary Objectives: Stage I: Determine clinical features that predict for greater benefit from adaptive planning Stage I: Determine the potential dosimetric benefit of SMART for central lung tumor Stage II: Determine the safety and efficacy of SMART for central lung tumors treated with 50Gy in 4-5 fractions. Exploratory objectives: Validate cine imaging and motion management strategies on the MR-linac

Conditions

• Lung Cancer

Interventions

Type	Name	Description
OTHER	Simulated Online Adaptive Planning	The results of the MRI-guided radiation therapy will be compared to conventional radiation therapy (guided by CT scans) during this study
RADIATION	Stereotactic MRI-guided adaptive radiotherapy-SMART	The results of the MRI-guided radiation therapy will be compared to conventional radiation therapy (guided by CT scans) during this study

Timeline

• Start date: 2022-11-17
• Primary completion: 2025-11-05
• Completion: 2025-11-05
• First posted: 2022-11-08
• Last updated: 2025-11-10

Locations

1 site across 1 country: United States