NCT05608356

Effect of Injectable Platelet-rich Fibrin on the En Masse Retraction of Maxillary Anterior Teeth

Effect of Injectable Platelet-rich Fibrin (i-PRF) on the Rate of Orthodontic En Masse Retraction of Maxillary Anterior Teeth: A Randomized Controlled Clinical Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 16 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to investigate the effect of local injection of injectable platelet rich fibrin (i-PRF) on the rate of orthodontic en masse retraction of anterior teeth clinically and to report any associated pain as well.

Detailed description

Trial will be carried on 2 groups, each involve 13 participants with a total of 26 participants. 1. Subject examination to ensure he/she meets the eligibility criteria of the research. 2. Leveling and alignment using fixed orthodontic appliance. 3. Upper first premolars extraction as a part of the orthodontic treatment planning. 4. With the starting of en masse retraction, injection of the (i-prf) obtained from venous sample palatally and distally to the anterior teeth in the intervention group, and sham injection in the control group. The injection in both groups will be done just before retraction, 21 and 42 days after beginning of retraction Rate of en masse retraction will be calculated for patients in both groups at the monthly basis for for months after starting en masse retraction, data will be analyzed statistically.

Conditions

• Platelet-rich Fibrin

Interventions

Type	Name	Description
BIOLOGICAL	injectable platelet rich fibrin(i-prf)	I-prf is a second-generation PRP where autologous platelets and leukocytes are present in a complex fibrin matrix and can be obtained from blood using low-speed centrifugation without adding anticoagulants.
DRUG	Sham Injection	Sham injection as a placebo injection

Timeline

• Start date: 2022-12-01
• Primary completion: 2023-11-30
• Completion: 2023-11-30
• First posted: 2022-11-08
• Last updated: 2022-11-08

Locations

1 site across 1 country: Egypt