NCT05607901

A Comparative Clinical Trial Evaluating the Effect and Safety of Tacrolimus Versus Hydrocortisone

A Comparative Clinical Trial Evaluating the Effect and Safety of Tacrolimus Versus Hydrocortisone in Management of Atopic Dermatitis in Children

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 2 Years – 16 Years
• Healthy volunteers: Not accepted

Summary

One of the most frequent skin conditions is atopic dermatitis (AD), characterized by its pruritic inflammation effect. Where the prevalence of AD increased in the last three decades by two or three folds worldwide, especially in developed countries, AD is supposed to affect about 15% to 30% of children, and 2% to 10% of adults. This type of dermatitis is frequently linked to a family history of other atopic illnesses such as allergic rhinitis or asthma.

Conditions

• Dermatologic Disease

Interventions

Type	Name	Description
DRUG	Tacrolimus ointment	tacrolimus is an immunosuppressive drug acting as an immunomodulator to assist manage acute flares and reducing the severity of future flares
DRUG	Hydrocortisone 1% cream	Topical corticosteroids (TCS) are the cornerstone for the management of AD to which other treatments are compared.

Timeline

• Start date: 2022-10-28
• Primary completion: 2023-11-20
• Completion: 2023-11-20
• First posted: 2022-11-07
• Last updated: 2025-04-08

Locations

1 site across 1 country: Egypt