NCT05605145

PCP in Immunocompromised Population in Southern China

Pneumocystis Pneumonia in Immunocompromised Population in Southern China：A Multicenter,Open,Prospective Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: First Affiliated Hospital of Guangxi Medical University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

To evaluate the sensitivity and specificity of the combined detection system for the diagnosis of pneumocystis infection in immunocompromised population in Southern China.

Detailed description

Pneumocystis jirovecii pneumonia (PJP) is a serious opportunistic infection in immunocompromised patients, with a difficult diagnosis, rapid progression and high mortality rate. The PJP mortality rate is high among patients with delayed diagnosis and treatment, and death is due to severe respiratory failure. Up to now, data regarding Pneumocystis jirovecii infection in immunocompromised patients is limited. In the present prospective study, the investigators aimed to evaluate the sensitivity and specificity of the combined detection system for the diagnosis of pneumocystis infection in immunocompromised population in Southern China.

Conditions

• Immunocompromised Patients
• Pneumocystis Pneumonia
• Diagnosis
• Polymerase Chain Reaction

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	PCR was used to detect pneumocystis in respiratory specimens	Respiratory tract specimens such as alveolar lavage fluid, sputum and throat swabs were collected from all patients who met the enrollment conditions of this study. qPCR and/or mNGS were used to detect pneumocystis in respiratory specimens.

Timeline

• Start date: 2021-05-12
• Primary completion: 2022-12-31
• Completion: 2023-06-30
• First posted: 2022-11-04
• Last updated: 2022-11-04

Locations

1 site across 1 country: China