NCT05604586

Assessment of the Impact of N-acetylcysteine Supplementation on Physical Performance

Assessment of the Impact of N-acetylcysteine Supplementation on Physical Performance Depending on the Polymorphism of Genes Related to Folate Metabolism

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Poznan University of Life Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Study aims to verify the hypothesis: * N-acetylcysteine (NAC) supplementation improves exercise capacity in people training endurance sports and the effectiveness of this supplementation depends on the polymorphism of genes related to folate and glutathione metabolism. * NAC supplementation affects the parameters of oxidative stress among women and men training endurance disciplines

Detailed description

* Glutathione depletion caused by a combination of intense physical exertion associated with the generation of significant amounts of reactive oxygen species (ROS), and possibly with having an unfavorable variant of the methylenetetrahydrofolate reductase (MTHFR), glutamate-cysteine ligase catalytic subunit (GCLC); glutamate-cysteine ligase modifier subunit (GCLM); glutathione S-transferase Pi 1 (GSTP1); glutathione synthetase (GSS) or cystathionine-β-synthase (CBS) genes may contribute to lower adaptation to exercise, but also to deterioration of health of people training endurance sports. * The main objective of the study is to verify the hypothesis that NAC supplementation has a beneficial effect on regeneration between intense exercise tests simulating a race characteristic for a given discipline. In addition, this study is aimed at checking whether genotype may modify the effectiveness of the supplementation measured as exercise and biochemical parameters . A double-blind study involving 100 women and men supplementing 1200 mg of N-acetylcysteine daily or 1200 mg of maltodextrin in three equal doses. Supplementation will last for 7 days. Blood sampling and body composition testing will be performed in the morning of the exercise test day. Discipline-specific exercise testing will be performed before and after the intervention.

Conditions

• Skeletal Muscle Performance
• Gene Polymorphisms

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	N-acetylcysteine	100 women and men supplementing 1200 mg of N-acetylcysteine daily in three equal doses. Supplementation will last for 7 days.
DIETARY_SUPPLEMENT	Placebo	100 women and men supplementing 1200 mg of placebo daily in three equal doses. Supplementation will last for 7 days.

Timeline

• Start date: 2022-05-01
• Primary completion: 2025-03-15
• Completion: 2025-12-31
• First posted: 2022-11-03
• Last updated: 2022-11-03

Locations

1 site across 1 country: Poland