NCT05604118

Platelet Enzymatically Oxidized Phospholipids (eoxPL) Characterisation in a Healthy Cohort on and Off Aspirin

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: Cardiff University · Academic / Other
• Sex: All
• Age: 20 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Healthy volunteers (n = 28) were recruited from the workplace (14 male, 14 female; age range 20-50 years). Ethical approval, which included informed consent, was from Cardiff University, Schools of Medicine and Dentistry Research Ethics Committee (SMREC16/02). Following a 2-week period free from non-steroidal anti-inflammatory drugs (NSAIDs), peripheral blood was obtained and platelets isolated. Participants were commenced on aspirin 75 mg once daily for seven days and then provided a repeat blood sample. Following a 2-month period, participants were invited to repeat samples pre- and post-aspirin, and again a third time 2 months later.

Conditions

• Platelet Dysfunction Due to Aspirin

Interventions

Type	Name	Description
DRUG	Aspirin	1 week of aspirin supplementation prior to sampling

Timeline

• Start date: 2016-08-01
• Primary completion: 2018-08-01
• Completion: 2022-06-01
• First posted: 2022-11-03
• Last updated: 2022-11-03

Locations

1 site across 1 country: United Kingdom