NCT05603988

Evaluation of The Effect of 980nm Diode Laser Intracanal Irradiation on Levels of Interleukin-8 Expression

Evaluation of The Effect of 980nm Diode Laser Intracanal Irradiation on Levels of Interleukin-8 Expression in Lesions Refractory to Endodontic Treatment: A Randomized Control Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

This clinical trial will be conducted to evaluate the amount of Il-8 expression before and after the application of intracanal irradiation with diode laser 980 nm versus placebo in failed endodontic cases with periapical lesions.

Detailed description

* Thorough medical and dental history for the eligible patients * Thorough intraoral and extraoral diagnosis * Local anesthesia * Isolation and removal of any previous filling or restoration * Removal of old gutta percha and establish patency to the full working length. * 1st sample: will be collected using 3 sterile paper points * Chemo-mechanical preparation. * 2nd sample collection • Laser group: The canals will be irradiated with a high-power diode laser, with wavelength of 980 nm, maximum output of 3 watts and coupled with a fiber optic tip of 200 µm diameter. • Mock laser application (Placebo group): The fiberoptic tip will be inserted inside the root canal, mimicking the laser irradiation, but not activated. * 3rd sample collection * A piece of dry cotton will be placed in the access cavity, and then will be sealed with glass ionomer filling material * 2nd visit: 1 week later, 4th sample collection then Obturation * Number of visits \& follow up period: Two visits

Conditions

• Endodontically Treated Teeth

Interventions

Type	Name	Description
DEVICE	Intracanal Diode laser irradiation	After endodontic retreatment, root canals will be irradiated with a 980 nm diode laser coupled with optical fibre 200 μm (Litemedics, Italy) with setting 1.2-watt power, in pulsed mode. The irradiation protocol will be of 5-sec irradiation followed by a 10-sec pause, which constituted one lasing cycle. The lasing cycle will be performed four times for each tooth. The tip will be positioned 1 mm short of the apex. Followed by activation during which it will be slowly dragged at a speed of approximately 2 mm/ sec in a way that the root canals will be irradiated from the apical to the coronal portion, in a helicoidal movement touching the canal walls.
OTHER	Placebo	After endodontic retreatment, mock laser application (Placebo group) will be applied: The fiberoptic tip will be inserted inside the root canal, mimicking the laser irradiation group, but not activated

Timeline

• Start date: 2021-04-14
• Primary completion: 2022-03-22
• Completion: 2022-04-27
• First posted: 2022-11-03
• Last updated: 2023-08-21

Locations

1 site across 1 country: Egypt