NCT05602519

The Analgesic Efficacy of Oxycodone Hydrochloride Versus Fentanyl After Total Hip Arthroplasty:

The Analgesic Efficacy and Safety of Oxycodone Hydrochloride Versus Fentanyl After Total Hip Arthroplasty: A Randomized Triple-Blind Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 72 (actual)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 28 Years – 62 Years
• Healthy volunteers: Not accepted

Summary

Oxycodone showed similar or superior analgesic effects than fentanyl and was proposed as an alternative for fentanyl for pain control in the postoperative period. However, it was mainly directed to control visceral pain, due to the mediation of analgesic effects by the kappa receptors. However, few studies compared the oxycodone to fentanyl for postoperative pain relief in patients undergoing total hip arthroplasty (replacement). Therefore, we established this randomized study to compare the efficacy of oxycodone and fentanyl for relief of postoperative pain after total hip arthroplasty (replacement).

Conditions

• Total Hip Arthroplasty
• The Analgesic Efficacy

Interventions

Type	Name	Description
DRUG	propofol, rocuronium and fentanyl	In fentanyl group (36 patients), 50 ug of fentanyl, and in oxycodone group, 4 mg of oxycodone will be administered 20 minutes before the end of the surgery, in triple blind manner.

Timeline

• Start date: 2022-11-10
• Primary completion: 2023-05-30
• Completion: 2023-05-30
• First posted: 2022-11-02
• Last updated: 2023-08-07

Locations

1 site across 1 country: Egypt