NCT05600413

Citrulline Supplementation On Vascular Responsiveness and Function in Postmenopausal Women

L-Citrulline Supplementation to Improve Vascular Function and Responsiveness at Rest and During Exercise in Postmenopausal Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: Texas Tech University · Academic / Other
• Sex: Female
• Age: 50 Years – 79 Years
• Healthy volunteers: Accepted

Summary

The objective of this project is to provide evidence that L-Citrulline (L-CIT) supplementation can improve vascular function at rest and in response to exercise in postmenopausal women.

Detailed description

L-CIT is a non-essential amino acid that is a precursor to L-arginine, the substrate used to produce an important vasodilatory molecule called nitric oxide. The purpose of this study is to identify the effects of 6 grams of L-CIT for 4 weeks on vascular function (endothelial function, blood flow, muscle oxygenation, and blood pressure) at rest and in response to different stressors (cold pressor test, isometric and dynamic exercise).

Conditions

• Menopause

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	L-Citrulline	4 weeks of L-Citrulline supplementation (6 grams/day)
DIETARY_SUPPLEMENT	Placebo	4 weeks of Placebo (crystalline cellulose)

Timeline

• Start date: 2020-07-07
• Primary completion: 2022-04-27
• Completion: 2022-04-27
• First posted: 2022-10-31
• Last updated: 2022-10-31

Locations

1 site across 1 country: United States