NCT05599490

Brain Enhancement Training Towards Elders Resilience to Aging, Phase IIB

BETTER Aging Trial: Brain Enhancement Training Towards Elders Resilience to Aging, Phase IIB

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 135 (actual)
• Sponsor: Posit Science Corporation · Industry
• Sex: All
• Age: 70 Years
• Healthy volunteers: Accepted

Summary

This study aims to examine the longer-term benefits of a novel, neuroplasticity-based, computerized and web-deliverable training program (PACR-CT) five years from the initial 10 weeks of training from our Phase II study - Protocol #: PSC-0605-17 (Aim 1) and test the interactive effect of previous training and 10 weeks of booster training (Aim 2). Both the study and the software being investigated meet the criteria of Non-Significant Risk.

Detailed description

This study will employ a single arm, open label design with use of the PACR-CT with all participants who completed the Phase II study, as well as approximately 60 new participants (with a goal of 40 completers) who are age-matched and untrained older adults. After consent, only the new, untrained participants will complete the screening visit. Then all participants will perform the pre-training visit (cognitive and functional assessments, MRI/fMRI and blood draw), followed by 10 weeks of training, and then followed by post-training visit (cognitive and functional assessments and MRI/fMRI).

Conditions

• Age-related Cognitive Decline

Interventions

Type	Name	Description
OTHER	Computerized Plasticity-Based Adaptive Cognitive Training	Forty-two minutes of training on computerized exercises that targets processing speed, memory and attention.

Timeline

• Start date: 2023-12-14
• Primary completion: 2026-01-28
• Completion: 2026-01-28
• First posted: 2022-10-31
• Last updated: 2026-02-19

Locations

2 sites across 1 country: United States