NCT05597033

Exercise and Vascular Function in Postmenopausal Females With Hypertension

The Effects of Exercise Time of Day on Blood Pressure and Vascular Function

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 68 (actual)
• Sponsor: Michigan State University · Academic / Other
• Sex: Female
• Age: 55 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The treatment of high blood pressure, or hypertension, is multifaceted and can include pharmacological therapies (i.e., medications) and lifestyle modifications such as physical activity. Chronotherapy, which describes timing of a treatment with the body's daily rhythms, has recently been used with hypertension medications and has been shown to be effective at lowering blood pressure and reducing the risk of cardiovascular disease events. Specifically, taking medications in the evening was shown to be more effective than morning medication routines. Little information is available about the effectiveness of chronotherapy combined with exercise (i.e., planned physical activity) interventions in older adults with hypertension. The purpose of this study is to examine how exercise performed in the morning and early evening affects blood pressure and other measures of blood vessel health in postmenopausal females with hypertension.

Detailed description

Blood pressure has an internal rhythm associated with the 24-hr clock. Nocturnal blood pressure (BP) is a key contributor to cardiovascular health and may be improved by exercise. Moreover, the time of day of the exercise may be a key factor. This study aims to evaluate the effect of evening exercise on BP and other measures of vascular function in older females with hypertension.

Conditions

• Hypertension

Interventions

Type	Name	Description
BEHAVIORAL	Exercise	walking and handgrip exercise
BEHAVIORAL	Control	seated rest

Timeline

• Start date: 2023-01-09
• Primary completion: 2025-06-24
• Completion: 2025-06-24
• First posted: 2022-10-27
• Last updated: 2026-01-15

Locations

1 site across 1 country: United States