NCT05594316

New Treatment of Alopecia Areata

Efficacy of Trichloroacetic Acid in Patients of Alopecia Areata : Clinico-histopathological Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 16 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Abstract: Alopecia areata is believed to be an autoimmune disease resulting from a breach in the immune privilege of the hair follicles causing non scarring hair loss. Methods: our study included 40 patients from may 2019 to july 2022 diagnosed clinically, dermatoscopically and pathologically as alopecia areata Data were enrolled from department of dermatology and venereology, Al-Hussein hospital.

Detailed description

For each patient the following will be done : 1. History taking including ( age, sex, disease duration, family history, history of drug intake, smoking and history of any associated disease ). 2. All patients will give a written, informed consent for induction. 3. Basic photographs will be taken to assess site, size (by cm), number, Extent of the patch using D5300 camera with lens (18-55). 4. Patients will be subjected to 3 session of trichloroacetic acid (TCA) 35% one month apart. 5. serial photographs and dermoscopic examination every month will be done and patient will be score. 6. Efficacy will be assessed using prognostic scoring system for density, pigmentation, and texture of growing hair. 7. histopathological examination will be done before the first session and one month after third session.

Conditions

• Alopecia Areata

Interventions

Type	Name	Description
DRUG	Trichloroacetic acid	5\. Patients will be subjected to 3 session of trichloroacetic acid 35% one month apart.

Timeline

• Start date: 2019-05-01
• Primary completion: 2022-08-01
• Completion: 2022-10-19
• First posted: 2022-10-26
• Last updated: 2022-10-26

Locations

2 sites across 1 country: Egypt