NCT05593107

68Ga-N188 PET/CT Imaging in Malignancy

A Study to Evaluate 68Ga-N188 PET/CT Imaging of Nectin-4 Expression in Malignant Tumors

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 203 (estimated)
• Sponsor: Peking University First Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The Nectin-4 protein belongs to the cell adhesion factors family and has a tissue-specific expression spectrum in normal human tissues. However, Nectin-4 is overexpressed in various malignancies, especially those of epithelial origins, such as uroepithelial carcinoma, making Nectin-4 a highly specific and significant imaging target for malignancies. \[68Ga\]N188, a novel molecular probe of PET imaging agent that targets Nectin-4, can be used in the diagnosis and research of a wide variety of Nectin-4 high-expression malignancies, including bladder cancer.

Conditions

• Neoplasms

Interventions

Type	Name	Description
DRUG	[68Ga]N188	68Ga-N188 is injected intravenously with a dose of 0.06-0.08 mCi/kg.

Timeline

• Start date: 2022-08-12
• Primary completion: 2025-07-31
• Completion: 2025-07-31
• First posted: 2022-10-25
• Last updated: 2024-11-21

Locations

1 site across 1 country: China