NCT05590936

Dimenydrinate vs Ondansetron for PONV (DONV)

Comparison of the Effectiveness of Dimenydrinate vs Ondasetron on the Prevention of Postoperative Nausea and Vomiting

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 190 (actual)
• Sponsor: University of Thessaly · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study will investigate the impact of dimenydrinate (H1-receptor antagonist) versus ondansetron (HT3-receptor antagonist) in postoperative nausea and vomiting, in surgery-related preoperative stress and in the incidence of postoperative complications that could lengthen the LOS in PACU and/or the overall LOS.

Detailed description

Dimenydrinate has been extensively used for motion sickness. However, as far as postoperative nausea and vomiting is concerned the results are still conflicting. This study will investigate the impact of dimenydrinate (H1-receptor antagonist) versus ondansetron (HT3-receptor antagonist) in postoperative nausea and vomiting, in surgery-related preoperative stress and in the incidence of postoperative complications that could lengthen the LOS in PACU and/or the overall LOS.

Conditions

• PONV in Laparoscopic Cholocystectomies

Interventions

Type	Name	Description
DRUG	Dimenhydrinate Tablets	2 hours preoperative per os administration of 50 mg dimenhydrinate
DRUG	Ondansetron iv	Intraoperative intravenous administration of 4 mg ondansetron

Timeline

• Start date: 2018-01-01
• Primary completion: 2022-12-07
• Completion: 2022-12-07
• First posted: 2022-10-21
• Last updated: 2022-12-08

Locations

1 site across 1 country: Greece