Trials / Unknown
UnknownNCT05590520
Comparison of Injections of Botulinum Toxin and Topical Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure
A Comparison of Injections of Botulinum Toxin and Topical Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure :A Randomized Controlled Trial
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 90 (estimated)
- Sponsor
- Pak Emirates Military Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Accepted
Summary
Patients will be randomized to receive treatment with either a total of 20 U of botulinum toxin(diluted in saline to a concentration of 50 U per milliliter.
Detailed description
Lateral internal sphincterotomy, the most common treatment for chronic anal fissure, may cause permanent injury to the anal sphincter, which can lead to fecal incontinence. We compared two nonsurgical treatments that avert the risk of fecal incontinence.treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Botulinum injection | Botox injection to be injected in internal anal sphincter to see the curative response in comparison to gtn cream application |
| DRUG | GTN OINTMENT | 0.2%GTN applied on anal canal. |
Timeline
- Start date
- 2022-11-01
- Primary completion
- 2023-11-01
- Completion
- 2024-12-01
- First posted
- 2022-10-21
- Last updated
- 2023-03-29
Locations
1 site across 1 country: Pakistan
Source: ClinicalTrials.gov record NCT05590520. Inclusion in this directory is not an endorsement.