NCT05589974

Choroidal Blood Flow in Acute and Chronic Central Serous Chorioretinopathy

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Helse Stavanger HF · Other Government
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Patients with central serous chorioretinopathy (CSC) will be monitored with laser speckle flow graphy (LSFG), swept source optical coherence tomography (SS-OCT) and SS-OCT angiography (SS-OCTA). The aim is to unveil the flow and pulse wave characteristics of the choroidal circulation in acute CSC and chronic CSC.

Detailed description

Acute CSC - The proposed study tests the hypothesis that choroidal blood flow characteristics are related to the eventual resolution of subretinal fluid. Such relation can shed light on pathophysiological disease mechanisms and constitute a biomarker for disease activity. Chronic CSC - The proposed study tests the hypothesis that choroidal blood flow characteristics will change in response to standard treatment with PDT. The research of such changes will increase the understanding of the treatment response. This knowledge will help in the effort to understand the why some patients are non-responsive to the treatment.

Conditions

• Central Serous Chorioretinopathy

Interventions

Type	Name	Description
DRUG	Verteporfin	Chronic CSC are receiving one treatment before the observation period.

Timeline

• Start date: 2022-10-01
• Primary completion: 2025-12-31
• Completion: 2026-07-31
• First posted: 2022-10-21
• Last updated: 2024-03-18

Locations

1 site across 1 country: Norway