NCT05589662

Clinical, Functional and Musculoskeletal Differences Between Adult Patients With Hemophilia and Their Healthy Peers

Analysis of Clinical, Functional and Musculoskeletal Variables Between Adult Patients With Hemophilic Arthropathy of the Knee and Ankle and Their Healthy Peers. A Case-control Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 42 (estimated)
• Sponsor: Investigación en Hemofilia y Fisioterapia · Network
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: —

Summary

Background. Hemophilia is characterized by the development of a progressive, degenerative, intra-articular lesion (hemophilic arthropathy). This arthropathy presents with chronic pain, limited range of motion, axial changes, and periarticular muscle atrophy. Goal. To analyze the clonic, functional and musculoskeletal differences between adult patients with hemophilic arthropathy of the knee and ankle and their healthy peers. Study design. Cases and controls study patients. 21 patients with hemophilia A and B and 21 subjects without joint damage. Variables and measuring instruments: pressure pain threshold (pressure algometer); joint status (Hemophilia Joint Health Score scale); and strength (dynamometry) and muscle activation (surface electromyography). Expected results. Observe the differences between patients with knee and ankle arthropathy and their healthy peers in muscle strength and activation.

Conditions

• Hemophilia Arthropathy

Interventions

Type	Name	Description
OTHER	Clinical and functional assessment	The dependent variables (muscle strength, muscle activation, pressure pain threshold and joint status) and the outcome measures used to measure these variables will be: pressure dynamometer, surface electromyography, pressure algometer and Hemophilia Joint Health Score

Timeline

• Start date: 2022-11-21
• Primary completion: 2022-11-28
• Completion: 2022-12-23
• First posted: 2022-10-21
• Last updated: 2022-11-04