NCT05586477

Diphenhydramine and Sweating

Does Diphenhydramine Alter Thermoregulatory Responses During Exercise?

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Lakehead University · Academic / Other
• Sex: All
• Age: 18 Years – 49 Years
• Healthy volunteers: Accepted

Summary

In 2012, it was estimated that nearly 1 in 4 Canadians suffer from allergic rhinitis. To add, 78% of individuals working in predisposing environments are predicted to develop occupational rhinitis. Currently, the most popular treatment for rhinitis is antihistamine medication such as diphenhydramine, a first-generation antihistamine sold commercially as Benadryl®. Due it its anticholinergic effects, diphenhydramine has been suggested to impair the whole body sweating response during heat stress, potentially leaving consumers at an increased risk of heat-related illness. This randomized control trial approved by Health Canada will investigate whether ingesting extra strength diphenhydramine (50mg) will alter whole-body sweat losses during 60 minutes of exercise.

Conditions

• Diphenhydramine Causing Adverse Effects in Therapeutic Use
• Hyperthermia
• Allergic Rhinitis
• Sweating

Interventions

Type	Name	Description
DRUG	Placebo	A placebo pill (i.e., sugar) will be consumed 2 h before intervention.
DRUG	Diphenhydramine	Extra strength Benadryl (DIN 02470144) will be consumed 2 h before intervention

Timeline

• Start date: 2022-11-21
• Primary completion: 2023-06-23
• Completion: 2023-06-23
• First posted: 2022-10-19
• Last updated: 2023-09-13

Locations

1 site across 1 country: Canada