NCT05583643

Clinical & Biochemical Effect of Atorvastatin in Nano Particles Gel in Periodontitis Treatment

Syringeable Atorvastatin Loaded Eugenol Enriched PEGylated Cubosomes In-situ Gel for the Intra-pocket Treatment of Periodontitis: Statistical Optimization and Clinical Assessment

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Misr University for Science and Technology · Academic / Other
• Sex: All
• Age: 25 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Periodontitis is a destructive chronic inflammatory disease characterized by periodontium damage and pocket formation between the tooth and the gingival margin resulting in ultimate tooth loss. Various topical anti-inflammatory drugs were used to treat inflammation in periodontitis. Introducing atorvastatin as a novel remedy for periodontitis treatment necessitates developing a syringeable modified delivery system capable of targeting inflammation within the periodontal pockets.

Conditions

• Periodontitis

Interventions

Type	Name	Description
DRUG	Atorvastatin Calcium	Atorvastatin loaded into nano particles in-situ gel adjunctive to scaling and debridement
DRUG	Atorvastatin Calcium	Atorvastatin loaded into in-situ gel adjunctive to scaling and debridement
OTHER	Scaling and debridement only	Scaling and debridement only

Timeline

• Start date: 2021-12-07
• Primary completion: 2022-04-15
• Completion: 2022-06-30
• First posted: 2022-10-18
• Last updated: 2022-10-19

Locations

1 site across 1 country: Egypt