NCT05583214

Evaluating the Effectiveness of Ondansetron Versus Dexamethasone Versus Placebo for the Control of Intraoperative Nausea and Vomiting in Patients Undergoing Lower-segment Caesarean Section Under Spinal Anesthesia

Comparing the Efficacy of Ondansetron, Dexamethasone, and Placebo for the Reduction of Intraoperative Nausea and Vomiting in Patients Undergoing Lower-segment Caesarean Section Under Spinal Anesthesia

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Muhammad Mubariz · Academic / Other
• Sex: Female
• Age: 20 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The goal of this randomized controlled trial is to evaluate the effectiveness of Ondansetron, Dexamethasone, and Placebo for intraoperative nausea and vomiting in patients undergoing caesarian section under spinal anesthesia. The main question it aims to answer are: Which drug is the best at reducing the incidence of intraoperative nausea and vomiting. Which drug is the best at reducing intraoperative pain. Participants will be randomly divided into three groups, each will be given a different drug labelled A, B, or C. A rating scale will be used to evaluate the severity of intraoperative nausea and pain. Episodes of vomiting will be recorded. Data collected from the three groups will be analyzed using SPSS software.

Conditions

• Caesarean Section
• Spinal Anesthesia

Interventions

Type	Name	Description
DRUG	Ondansetron 8mg	8mg of Ondansetron IV stat will be given to the group after induction of spinal anesthesia
DRUG	Dexamethasone 8mg	8mg of Dexamethasone IV stat will be given to the group after induction of spinal anesthesia
DRUG	Normal saline	Normal saline will be given IV stat to the group after induction of spinal anesthesia

Timeline

• Start date: 2022-10-01
• Primary completion: 2022-12-01
• Completion: 2023-01-01
• First posted: 2022-10-17
• Last updated: 2022-10-18

Locations

1 site across 1 country: Pakistan