NCT05582941

Biomarkers of Cognitive Impairment in Blood Cells

Use of Human Blood Cells for the Identification of Early Biomarkers of Cognitive Damage

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 48 (actual)
• Sponsor: University of the Balearic Islands · Academic / Other
• Sex: All
• Age: 55 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to identify transcriptomic biomarkers in blood cells to diagnose early cognitive impairment. This would allow preventing the development of severe pathologies, such as Alzheimer Disease. In addition, this project will analyse the influence of adiposity, obesity, nutritional habits and physical activity on cognition.

Detailed description

Blood cells constitute a minimally invasive material, which is presented as potentially suitable for addressing the identification of clinical diagnostic biomarkers. This study will compare gene expression in blood cells of patients with various degrees of cognitive alteration (mild cognitive impairment due to Alzheimer's disease and dementia due to Alzheimer's Disease) compared to control individuals, to identify early biomarkers of impaired cognition. The availability of non-invasive early biomarkers of cognitive dysfunction is highly relevant in the field of public health, from the point of view of being able to prevent or delay the onset and/or progression of dementia and other cognitive disorders. In addition, it is intended to establish the association between the biomarkers identified with nutritional imbalances and increased adiposity/obesity.

Conditions

• Mild Cognitive Impairment Due to Alzheimer's Disease
• Dementia Due to Alzheimer's Disease (Disorder)

Interventions

Type	Name	Description
OTHER	No intervention will be performed.	No intervention will be performed.

Timeline

• Start date: 2022-04-01
• Primary completion: 2023-05-31
• Completion: 2023-05-31
• First posted: 2022-10-17
• Last updated: 2025-07-04

Locations

1 site across 1 country: Spain