NCT05581615

Influence of Food Matrix on Prebiotic Efficacy in Inulin Type Fructans

Randomized Four-arm Trial Investigating the Effects of Different Food Matrices on the Prebiotic Efficacy of Inulin Type Fructans (ITF) From Chicory Root

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 96 (actual)
• Sponsor: Beneo-Institute · Industry
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to investigate whether the food matrix has an influence on the prebiotic efficacy (bifidobacteria growth) of chicory-derived Orafti® inulin in healthy adult volunteers. The main question it aims to answer is: Does the food matrix influence the prebiotic effect of chicory-derived inulin in terms of stimulation of bifidobacteria in the gut microbiota Participants will receive one of three food items containing inulin or pure inulin dissolved in water daily for 10 days. The food items or pure inulin powder will deliver 10 g/d inulin split into two dosages of 5 g/d. They will provide stool samples before and at the end of the intake period. They will record any gastrointestinal sensations and bowel habits in a diary. Urinary samples will be collected at baseline and end of intervention for analysis of metabolites with Nuclear Magnetic resonance (NMR).

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Inulin	Each intervention provided 10 g/d inulin split into two dosages of 5 g.

Timeline

• Start date: 2020-11-20
• Primary completion: 2021-05-22
• Completion: 2021-10-06
• First posted: 2022-10-14
• Last updated: 2022-12-21

Locations

1 site across 1 country: United Kingdom