NCT05579665

Effectiveness of PRP, Conditioned Medium UC-MSCs Secretome and Hyaluronic Acid for the Treatment of Knee Osteoarthritis

Comparative Effectiveness of Platelet Rich Plasma (PRP), Conditioned Medium From Umbilical Cord Mesenchymal Stem Cell Culture (MSCs) Secretome and Hyaluronic Acid (HA) for the Treatment of Knee Osteoarthritis

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: Universitas Sriwijaya · Academic / Other
• Sex: All
• Age: 30 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The clinical trial will be carried out at the Dr. Moh. Hoesin Central Hospital, Palembang and planned from October 2022 to March 2023. This study aims to compare the efficacy of Platelet Rich Plasma, Conditioned Medium From Umbilical Cord Mesenchymal Stem Cell (MSC) Culture Secretome and hyaluronic acid for the Treatment of Knee Osteoarthritis

Detailed description

In this, prospective, Open-label study, patients with mild to moderate symptomatic knee osteoarthritis will be randomized to receive either a series of platelet-rich plasma or hyaluronic acid or Conditioned Medium From Umbilical Cord Mesenchymal Stem Cell (MSC) Culture Secretome injections under ultrasound guidance. Each of the groups were given 5 times injection 3 cc platelet-rich plasma or 2 cc hyaluronic acid or 2cc Conditioned Medium From Umbilical Cord MSC Secretome at intervals 1 weeks. Clinical data in the form of subjective outcome measures will be collected pre-treatment and 6 months after injection.

Conditions

• Knee Osteoarthritis

Interventions

Type	Name	Description
BIOLOGICAL	Platelet-rich Plasma	Research participants own blood will be used to prepare the platelet rich plasma injectate.
BIOLOGICAL	Conditioned Medium From Umbilical Cord Mesenchymal Stem Cell Culture (MSCs) Secretome	Conditioned Medium UC-MSCs Secretome which will be injected into the affected knee using ultrasound guidance.
DRUG	Low Molecular Weight Hyaluronic Acid	low molecular weight hyaluronic acid which will be injected into the affected knee using ultrasound guidance.

Timeline

• Start date: 2022-10-02
• Primary completion: 2023-03-31
• Completion: 2023-05-31
• First posted: 2022-10-14
• Last updated: 2023-10-31

Locations

1 site across 1 country: Indonesia