NCT05577039

Preoperative RRI and Long-term Risk for CKD

Preoperative Renal Resistive Index to Predict Long-term Development of Chronic Kidney Disease in Patients Undergoing Cardiac Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 96 (actual)
• Sponsor: Region Stockholm · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Renal resistive index (RRI) is calculated from ultrasonographic Doppler measurements of flow velocities in intraparenchymal renal arteries. Normal values are around 0.60, and 0.70 is considered the upper normal threshold in adults. Both preoperative and postoperative elevation of RRI has shown promise in early detection of AKI after cardiac surgery. Further, elevated RRI before coronary angiography is associated with an increased risk of cardiovascular complications up to 1 year after the procedure. The role of preoperative RRI in predicting long-term renal and cardiovascular complications after elective surgery is however not known. The aim of this study is to assess the role of preoperative RRI to predict the risk of persistent renal dysfunction as well as renal- and cardiovascular complications up to 5 years after surgery.

Conditions

• Acute Kidney Injury
• Acute Kidney Disease
• Chronic Kidney Disease
• Cardiac Surgery
• Renal Resistive Index

Timeline

• Start date: 2022-11-01
• Primary completion: 2023-06-01
• Completion: 2023-09-01
• First posted: 2022-10-13
• Last updated: 2023-11-24

Locations

1 site across 1 country: Sweden