NCT05575752

Acute Health Effects of High Temperature Exposure

Acute Health Effects of High Temperature Exposure in Healthy Young Adults: a Randomized Controlled Study

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Fudan University · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of high temperature exposure and the underlying mechanisms.

Detailed description

The investigators will conduct a randomized controlled human exposure crossover study among about 30 healthy young adults in Shanghai, China. Each subject will be exposed twice: once to the high temperature (32℃) and once to moderate temperature (22℃) in a chamber for about 2 hours. During the exposure session, each subject will be requested to rest. Health examinations will be conducted immediately prior to exposure, during the period of exposure and after exposure. Health examinations include symptom questionnaire, blood pressure tests, cognitive function tests, magnetic resonance imaging, skin tests, spirometry, and Holter monitoring. Investigators plan to collect blood, urine and oropharyngeal swabs samples.

Conditions

• Cardiovascular System
• Respiratory System
• Cognitive Function

Interventions

Type	Name	Description
OTHER	high temperature (32℃) group	The exposure group will be exposed to high temperature (32℃) in a chamber for about 2 hours, resting during the whole periods.
OTHER	moderate temperature (22℃) group	The exposure group will be exposed to thermoneutral temperature (22℃) in a chamber for about 2 hours, resting during the whole periods.

Timeline

• Start date: 2022-10-23
• Primary completion: 2022-11-19
• Completion: 2026-12-31
• First posted: 2022-10-12
• Last updated: 2025-02-26

Locations

1 site across 1 country: China