NCT05574894

Effect of GH Supplementation on the Blastocyst Euploid Rate in AMA Patients--A Retrospective Cohort Study

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 692 (actual)
• Sponsor: ShangHai Ji Ai Genetics & IVF Institute · Academic / Other
• Sex: Female
• Age: 38 Years – 46 Years
• Healthy volunteers: Not accepted

Summary

This retrospective cohort study aims to investigate the effects of recombinant human growth hormone (rh-GH) on the euploid status of preimplantation blastocysts in AMA patients. Infertile patients aged 38-46 years old were recruited for study if they fulfill the inclusion criteria and do not have the exclusion criteria. Treatment group: Women received growth hormone (GH) supplement during antagonist protocol for ovarian stimulation. Control group: Women received antagonist protocol for ovarian stimulation. The primary outcome is the euploidy rate of blastocysts per stimulation cycle and per testing cycle.

Conditions

• Growth Hormone
• Advanced Maternal Age
• PGT-A

Interventions

Type	Name	Description
DRUG	Growth hormone	Growth hormone is supplemented during the ovarian stimulation till the day of trigger
DRUG	GnRH antagonist	GnRH antagonist protocol for ovarian stimulation

Timeline

• Start date: 2021-01-01
• Primary completion: 2022-06-30
• Completion: 2022-09-30
• First posted: 2022-10-12
• Last updated: 2023-02-21

Locations

1 site across 1 country: China