NCT05571605

Cerebrovascular Dysregulation in Chronic Kidney Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: University of North Texas, Denton, TX · Academic / Other
• Sex: All
• Age: 30 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to test whether or not regular exercise training may improve brain blood flow regulation in patients with chronic kidney disease (CKD).

Detailed description

Prior research has shown that CKD patients have an increased risk of stroke and that impairments in brain blood flow regulation predict stroke in other chronic disease states. This study will test whether exercise training can improve brain blood flow regulation via improved dynamic cerebral autoregulation and cerebrovascular carbon dioxide reactivity in CKD. Participants will undergo exercise training on a stationary bicycle, or stretching exercises, 3 times per week for 12 weeks.

Conditions

• Chronic Kidney Diseases

Interventions

Type	Name	Description
BEHAVIORAL	Exercise	Participants randomized to this arm will exercise on a stationary bicycle.
BEHAVIORAL	Stretching	Participants randomized to this arm will perform stretching and balance exercise.

Timeline

• Start date: 2022-08-01
• Primary completion: 2025-02-28
• Completion: 2025-03-31
• First posted: 2022-10-07
• Last updated: 2025-07-20
• Results posted: 2025-07-20

Locations

1 site across 1 country: United States