NCT05567809

Defining Exercise Hemodynamics and Function After Transcatheter Aortic Valve Replacement (DEFINE-TAVR) Study.

DEFINE-TAVR (Defining Exercise Hemodynamics and Function After Transcatheter Aortic Valve Replacement) Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 28 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

The purpose of this study is to help understand how the replacement valve functions over time, both at rest and during exercise.

Detailed description

The objective of this single-center registry is to evaluate prosthetic valve hemodynamics and function over time in patients undergoing clinically indicated transcatheter aortic valve replacement (TAVR) for symptomatic severe aortic stenosis. Specific goals include: * Describe valve hemodynamics at rest (baseline, post-procedure, 30 days, 1 year) and with exercise (at 30 days and 1 year) after TAVR implantation to define valve function and hemodynamics over time. * Compare valve hemodynamics and function at rest and exercise between self-expanding and balloon expandable valves.

Conditions

• Aortic Valve Stenosis

Timeline

• Start date: 2022-10-25
• Primary completion: 2025-01-21
• Completion: 2025-01-21
• First posted: 2022-10-05
• Last updated: 2025-08-11

Locations

1 site across 1 country: United States