NCT05567692

Subjects With T2D or at Risk of T2D Cohort Follow-up

Descendance Cohort: Follow-up of Subjects With Type 2 Diabetes or at Risk of Type 2 Diabetes Defined by the Existence of the Disease in the Family in Two Successive Generations

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 837 (estimated)
• Sponsor: Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The main objective of this study is to prospectively follow the subjects included in "Descendance" cohort and to describe the occurrence of type 2 diabetes in non-diabetic subjects, which will allow us to iteratively update the "Descendance" Type 2 Diabetes risk prediction model.

Detailed description

High risk families will be prospectively follow in order to better understand the risk of transmission of type 2 diabetes from one generation to another. The cohort will also allow us to collect additional data on diabetic patients. The monitoring of the cohort will take place for at least 10 years with a follow-up of all participants every three years. To detect individuals who develop dysglycemia during the study, a glucose tolerance test (GTT) and HbA1c measurement will be conducted.

Conditions

• Diabetes Mellitus, Type 2

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	OGTT	Oral Glucose Tolerance Test
OTHER	HbA1c	HbA1c measurement
OTHER	Questionnaire	Follow-up questionnaire

Timeline

• Start date: 2023-02-10
• Primary completion: 2032-10-01
• Completion: 2032-10-01
• First posted: 2022-10-05
• Last updated: 2026-04-15

Locations

1 site across 1 country: France