NCT05567068

Atorvastatin Efficacy and Safety in Patients With Ulcerative Colitis

Repurposing Atorvastatin in Patients With Ulcerative Colitis Treated With Mesalamine by Modulation of mTOR/NLRP3 Pathway.

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 54 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Statins exert numerous pleiotropic effects including anti-inflammatory, antioxidant properties, endothelial function improvement, and immunomodulation independent of their basic lipid-lowering properties.

Conditions

• Inflammatory Bowel Diseases

Interventions

Type	Name	Description
DRUG	Atorvastatin 80mg	Atrovastatin is one of the most effective drugs used to reduce intracellular cholesterol synthesis. it exerts numerous pleiotropic effects including anti-inflammatory, antioxidant properties, endothelial function improvement and immunomodulation independent of its basic lipid-lowering properties
DRUG	Mesalamine	Mesalamine

Timeline

• Start date: 2023-02-01
• Primary completion: 2025-06-01
• Completion: 2025-06-01
• First posted: 2022-10-05
• Last updated: 2025-11-18

Locations

1 site across 1 country: Egypt