NCT05564130

Bicarbonate for In-Hospital Cardiac Arrest

Bicarbonate for In-Hospital Cardiac Arrest - A Randomized, Double-Blind, Placebo-Controlled Trial

• Status: Active Not Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 778 (estimated)
• Sponsor: Lars Wiuff Andersen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is an investigator-initiated, multicenter, randomized, placebo-controlled, parallel group, double-blind, superiority trial of sodium bicarbonate during adult in-hospital cardiac arrest. There will be 22 enrolling sites in Denmark. 778 adult patients with in-hospital cardiac arrest receiving at least one dose of adrenaline will be enrolled. The primary outcome is return of spontaneous circulation and key secondary outcomes include survival at 30 days and survival at 30 days with a favorable neurological outcome.

Conditions

• Cardiac Arrest

Interventions

Type	Name	Description
DRUG	Sodium bicarbonate	Sodium bicarbonate 1 mmol/ml
DRUG	Sodium chloride	Sodium chloride 9 mg/mL

Timeline

• Start date: 2023-02-06
• Primary completion: 2026-02-11
• Completion: 2027-02-11
• First posted: 2022-10-03
• Last updated: 2026-02-17

Locations

22 sites across 1 country: Denmark