NCT05560919

Acceleration of Orthodontic Tooth Movement

Evaluation of Clinical Efficacy of Locally Injected Vitamin D3 (Calcitriol or 1,25 Dihidroxicolecalciferol) in Accelerating Orthodontic Tooth Movement (A Randomized Controlled Trial)

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Tishreen University · Academic / Other
• Sex: All
• Age: 15 Years – 25 Years
• Healthy volunteers: Not accepted

Summary

EVALUATION OF EFFICACY OF LOCALLY INJECTED Vitamin D3 (calcitriol or 1.25 dihidroxicolecalciferol) IN ACCELERATING ORTHODONTIC MOVEMENT Design: A randomized, controlled, crossover, double-blind clinical study including Eighteen adult , aged 15-25 years old.

Detailed description

The rate of orthodontic tooth movement depends on two general factors: the forces used in order to cause orthodontic tooth movement and respectively the individual (biological) response of the body to these forces. There are many methods for accelerating orthodontic tooth movement. but, every method has its disadvantages, such as pain and root absorption. Locally injected of vitamin d3 was proposed to accelerates tooth movement with minimal disadvantages, but there aren't enough clinical studies to prove this claim.

Conditions

• Mild to Moderate Anterior Mandibular Segment Crowdind

Interventions

Type	Name	Description
DRUG	Dihydroxycholecalciferols	Injection of Dihydroxycholecalciferols solution in the periodontal ligament for lower anterior segment teeth.
OTHER	dimethyl sulfoxide	Injection of dimethyl sulfoxide in the periodontal ligament for lower anterior segment teeth.
OTHER	serum	Injection of serum in the periodontal ligament for lower anterior segment teeth.

Timeline

• Start date: 2021-09-20
• Primary completion: 2022-04-30
• Completion: 2022-06-25
• First posted: 2022-09-30
• Last updated: 2022-09-30

Locations

1 site across 1 country: Syria