NCT05559814

Intraluminal Peppermint Oil and Adenoma Detection Rate in Screening Colonoscopy

Intraluminal Peppermint Oil Can Increase Adenoma Detection Rate in Colon Cancer Screening Colonoscopy: A Double- Blinded Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 404 (actual)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Accepted

Summary

This is a prospective randomized placebo-controlled trial to evaluate the efficacy of peppermint oil spraying into the colonic lumen through the scope channel during screening colonoscopy. The primary outcome is to compare the colonic peristalsis between peppermint oil and placebo. The secondary outcomes compare the procedural time, polyp detection rate, adenoma detection rate, and adverse events.

Conditions

• Colonic Polyp

Interventions

Type	Name	Description
DRUG	Intraluminal peppermint oil	Intraluminal flushing of peppermint oil solution through the scope channel during the scope withdrawal
DRUG	Placebo	Intraluminal flushing of placebo solution through the scope during scope withdrawal

Timeline

• Start date: 2021-03-01
• Primary completion: 2022-05-31
• Completion: 2022-06-30
• First posted: 2022-09-29
• Last updated: 2023-04-05

Locations

1 site across 1 country: Thailand