NCT05558813

Natural History of Duchenne Muscular Dystrophy Cardiomyopathy (DMD-CMP)

Prospective Cardiac Magnetic Resonance Imaging Study in Duchenne Muscular Dystrophy (DMD-CMP)

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: Male
• Age: 6 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to describe the progression of tissular and functional myocardial abnormalities in patients with Duchenne muscular dystrophy using cardiac magnetic resonance imaging and blood biomarkers assays.

Detailed description

This study is to describe the progression of tissular (late gadolinium enhancement, T1, T2, ECV assessments) and functional (segmental and global contractility, strain) myocardial abnormalities in patients with Duchenne muscular dystrophy using cardiac magnetic resonance imaging and blood biomarkers assays (troponin I, NTproBNP). Comparison between baseline and 2-years assessments will be conducted.

Conditions

• Duchenne Muscular Dystrophy

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Cardiac MRI	two cardiac MRIs with Gadolinum injection at 2-year intervals
BIOLOGICAL	Blood assays	blood samples for the determination of blood biomarkers of heart failure (BNP, NTproBNP) and for the constitution of a biological collection

Timeline

• Start date: 2024-11-01
• Primary completion: 2029-02-01
• Completion: 2029-04-01
• First posted: 2022-09-28
• Last updated: 2025-11-20

Locations

1 site across 1 country: France