NCT05558566

Neurofeedback From the Supplementary Motor Area for Tourette Syndrome

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (estimated)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 10 Years – 16 Years
• Healthy volunteers: Not accepted

Summary

This is a clinical trial where adolescents aged 10-16 years old with Tourette Syndrome (or chronic tic disorder) are randomized to receive either real-time functional magnetic resonance imaging (fMRI) neurofeedback targeting the supplementary motor area (for the experimental intervention) or real-time fMRI neurofeedback (NF) from a control region (for the control intervention).

Detailed description

The training portion of this study involves three fMRI NF sessions, with six NF scans per session. NF scans alternate between up-regulate and down-regulate blocks in which participants are cued to increase or decrease activity in the target region while receiving feedback on activity in the region at the bottom of the screen in the form of a line graph. The experimental group receives feedback from the supplementary motor area (SMA) and the control group receives feedback from a control region of the brain.

Conditions

• Tourette Syndrome in Adolescence

Interventions

Type	Name	Description
OTHER	Neurofeedback from the SMA	Feedback is provided regarding activity in the SMA and participant attempts to control SMA activity using the feedback as a training signal
OTHER	Neurofeedback from control region	Feedback is provided regarding activity in a control region and participant attempts to control activity in that region using the feedback as a training signal.

Timeline

• Start date: 2022-11-01
• Primary completion: 2026-12-20
• Completion: 2027-01-20
• First posted: 2022-09-28
• Last updated: 2025-08-06

Locations

1 site across 1 country: United States