NCT05558384

Influence of Adiposity on IGF-1 and Fitness Response to Exercise in Cancer Survivors

The Influence of Excess Adiposity on Cardiorespiratory, Insulin-like Growth Factor, and Metabolic Responses to a Standardized Aerobic Exercise Program in Cancer Survivors

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: All
• Age: 21 Years – 79 Years
• Healthy volunteers: Not accepted

Summary

This is a pilot feasibility study of an investigation of the influence of excess adiposity on cardiorespiratory fitness (CRF), insulin-like growth factor-1 (IGF-1), and metabolic responses to a standardized aerobic exercise program in cancer survivors. This investigation attempts to isolate the influence of adiposity on these responses. We will enroll overweight, obese, and normal weight cancer survivors with a primary diagnosis of breast, prostate, or colorectal cancer who have completed all cancer-related treatment. Participants will engage in a 15-week aerobic exercise intervention with pre- and post-intervention assessments.

Conditions

• Cancer
• Overweight and Obesity

Interventions

Type	Name	Description
BEHAVIORAL	Aerobic Exercise	A 15-week standardized aerobic exercise intervention. * Frequency: 5 days/wk (2 supervised) * Intensity: 50-59% heart rate reserve * Time: 40 min/session (ramp up from 25-40 during first 4 weeks) * Type: Aerobic exercise (e.g. treadmill, walking/jogging, cycling, elliptical)

Timeline

• Start date: 2023-03-22
• Primary completion: 2024-10-01
• Completion: 2024-10-01
• First posted: 2022-09-28
• Last updated: 2025-02-24

Locations

1 site across 1 country: United States